Influence of the rhenium-platinum system as nanolyposomes on the proliferative activity of cancer cells

  • G. S. Kononova
  • S. V. Antonuk
  • N. I. Shtemenko Oles' Нonchar Dnіpropetrovsk National University

Abstract

Decrease of proliferative activity of the cells of Guerin’s carcinoma T8 in the different conditions of administration of the Rhenium-Platinum anti-tumour system as nanolyposomes is shown. The Rhenium-Platinum anti-tumour system influenced on the morphological indices of tumour tissue. The cluster rhenium compounds reduced the indices of pathological mitoses 3.0–3.6 times in comparison with a control group. The amount of PCNA-positive cells under the Rhenium-Platinum system treatment went down by 82.5–84.5 %. The anti-tumour system led to the predominance of apoptotic cell death over the necrotic one. The most effective agent was the compound with cis-adamantan organic ligand cis-Re2(C10H15COO)2Cl4·2DMSO introducted on the 9th day.

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Published
2011-03-30
How to Cite
Kononova, G. S., Antonuk, S. V., & Shtemenko, N. I. (2011). Influence of the rhenium-platinum system as nanolyposomes on the proliferative activity of cancer cells. Regulatory Mechanisms in Biosystems, 2(1), 59-67. https://doi.org/10.15421/021110