Hyaluronate and total hyaluronate-binding capacity of proteins under experimental chronic hepatitis C and treatment with alpha-ketoglutarate

  • O. Z. Fomenko Оles’ Gonchar Dnipropetrovsk National University
  • G. A. Ushakova Оles’ Gonchar Dnipropetrovsk National University
  • S. G. Pierzynowski Lund University, Sweden

Abstract

The increase of hyaluronic acid concentration in the blood serum of rats during modelling of chronic hepatitis C is presented. The research of changes in the absolute and relative hyaluronate-binding activity of cytosolic proteins in the rats’ cerebellum and hippocampus under normal condition, experimental chronic hepatitis C and with the alfa-ketoglutarate treatment was carried out.

References

Gandhi N. S. The structure of glycosaminoglycans and their interactions with proteins / N. S. Gandhi, R. L. Mancera // Chem. Biol. Drug. Des. – 2008. – Vol. 72, N 6. – P. 455–482.

Gold E. W. The quantitative spectrophotometric estimation of total sulfated glycosaminoglican levels // Biochemica et Biophysica Acta. – 1981. – Vol. 673. – P. 408–415.

Takashi Y., Rumi T., Toshie T. The effect of sulfated hyaluronan on the morphological transformation and activity of cultured human astrocytes / Y. Takashi, T. Rumi, T. Toshie // Biomaterials. – 2008. – Vol. 29. – Р. 3503–3513.

Ushakova G. Postnatal dynamics of the heparin-binding activity of rat cerebellar cells // Нейрофизиология / Neurophysiology. – 1999. – Vol. 31, N 2. – P. 140–141.

Пат. 15752 Україна, МПК G 09 B 23/28. Спосіб моделювання хронічного гепатиту С / В. Ю. Ніколенко, Ю. І. Ніколенко, О. Ю. Ніколенко; заявник та власник Донецький гос. мед. ун-т. – № u2006004614 заявл. 18.01.2006; набрано чинності 17.07.2006.

Ушакова Г. О. Роль глікозаміноглікан-зв’язуючих білків у морфогенезі та пластичності мозку. Автореф. дис. … д-ра біол. наук: Харк. нац. ун-т ім. В. Н. Каразіна. – Х., 2005. – 35 с.

Sheline C. T. Free radical-mediated neurotoxicity may be caused by inhibition of mitochondrial dehydrogenases in vitro and in vivo / C. T. Sheline, L. Wei // Neuroscience. – 2006. – Vol. 140, N 1. – P. 235–246.

The role of astrocytes and complement system in neural plasticity. / M. Pekny, U. Wilhelmsson, Y. R. Bogestаl, M. Pekna // Int. Rev. Neurobiol. – 2007. – Vol. 82. – P. 95–111.

2-Oxoglutarate downregulates expression of vascular endothelial growth factor and erythropoietin through decreasing hypoxia-inducible factor-1alpha and inhibits angiogenesis / K. Matsumoto, S. Imagawa, N. Obara et al. // J. Cell. Physiol. – 2006. – Vol. 209, N 2. – P. 333–340.

Dakshayani K. B. Alpha-ketoglutarate modulates the circadian patterns of lipid peroxidation and antioxidant status during N-nitrosodiethylamine-induced hepatocarcinogenesis in rats / K. B. Dakshayani, P. Subramanian // J. Med. Food. – 2006. – Vol. 9, N 1. – P. 90–97.

Published
2010-06-04
How to Cite
Fomenko, O. Z., Ushakova, G. A., & Pierzynowski, S. G. (2010). Hyaluronate and total hyaluronate-binding capacity of proteins under experimental chronic hepatitis C and treatment with alpha-ketoglutarate. Regulatory Mechanisms in Biosystems, 1(2), 85-89. https://doi.org/10.15421/021036